A general branching process model is proposed to describe the shortening of telomeres in eukariotic chromosomes. The model is flexible and incorporates many special cases to be found in the literature. In particular, we show how telomere shortening can give rise to sigmoidal growth curves, an idea first expressed by Portugal et al. (2008). We also demonstrate how other types of growth curves arise if telomere shortening is mitigated by other cellular processes. We compare our results to published data sets from the biological literature.
Document Object Identifier (DOI)
Oloffson, P. (2010). Can telomere shortening explain sigmoidal growth curves? Journal of Biological Dynamics, 4, 527-538. doi: 10.1080/17513750903377442
Journal of Biological Dynamics