Date of Award


Document Type

Thesis open access


Bateson-Dobzhansky-Muller Incompatibilities are theorized to be one of the main causes of post-zygotic reproductive isolating barriers. While many quantitative models for the development of such incompatibilities exist, few have dealt with the e ect the struc- ture of protein-interaction networks has on the development of incompatibilities, and none deal with incompatibilities between more than two loci. We develop a stochastic model for the development of complex Bateson-Dobzhansky-Muller incompatibilities that incorporates the structure of protein-protein interaction networks, and demonstrate that the structure of the network can drastically change the importance of digenic interactions toward the rate of divergence between populations.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.