This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy. This chemistry enables the synthesis of a broad range of asymmetric viologens in high yield at room temperature and is compatible with a wide range of functional groups, including amine, guanidinyl, thiol, carboxylic acid, phenol, and indole.
American Chemical Society
Reczek, J. J., Rebolini, E., & Urbach, A. R. (2010). Solid-phase synthesis of peptide-viologen conjugates. Journal of Organic Chemistry, 75(6), 2111-2114. https://doi.org/10.1021/jo100018f
Journal of Organic Chemistry