Document Type

Post-Print

Publication Date

2009

Abstract

A new family of guanidinium-rich molecular transporters featuring a novel oligocarbonate backbone with 1,7-side chain spacing is described. Conjugates can be rapidly assembled irrespective of length in a one-step oligomerization strategy that can proceed with concomitant introduction of probes (or by analogy drugs). The new transporters exhibit excellent cellular entry as determined by flow cytometry and fluorescence microscopy, and the functionality of their drug delivery capabilities was confirmed by the delivery of the bioluminescent small molecule probe luciferin and turnover by its intracellular target enzyme.

Document Object Identifier (DOI)

10.1021/ja907363k

Publisher

American Chemical Society

Publication Information

Journal of the American Chemical Society

Included in

Chemistry Commons

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