Thermoresponsive Double Network Micropollared Hydrogels for Controlled Cell Release
Document Type
Article
Publication Date
9-2014
Abstract
Thermoresponsive poly(N-isopropylacrylamide) hydrogels (PNIPAAm) have been widely used for controlled cell detachment. In this study, cell release is enhanced via deswelling with a two-pronged approach combining a double network (DN) design and micropatterning. PNIPAAm hydrogels are prepared as DNs comprised of a tightly crosslinked 1st network and a loosely crosslinked 2nd network. Moreover, the PNIPAAm DN hydrogels are prepared as both planar 1.5 mm-thick slabs as well as micropillar arrays (≈200 μm pillar diameter). Compared to the corresponding conventional single network (SN) hydrogels, DN hydrogels exhibit enhanced thermosensitivity and cell release efficiency, particularly for the micropillar arrays.
Identifier
10.1002/mabi.201400172
Publisher
Wiley-VCH Verlag
Repository Citation
Fei, R., Hou, H., Munoz-Pinto, D., Han, A., Hahn, M. S., & Grunlan, M. A. (2014). Thermoresponsive double network micropillared hydrogels for controlled cell release. Macromolecular Bioscience, 14(9), 1346-1352. doi:10.1002/mabi.201400172
Publication Information
Macromolecular Bioscience