Photodynamic therapy is a complex treatment for neoplastic diseases that uses the light-harvesting properties of a photosensitizer. The treatment depends on the amount of photosensitizer in the tissue and on the amount of light that is focused on the targeted area. We use a pharmacokinetic model to represent a photosensitizer's movement through the anatomy and design treatments with a linear program. This technique allows us to investigate how a treatment's success varies over time.
Document Object Identifier (DOI)
Holder, A., & LLagostera, D. (2008). Optimal treatments for photodynamic therapy. 4OR, 6(2), 167-182. doi:10.1007/s10288-007-0046-4