A general branching process model is suggested to describe cell cycle desynchronization. Cell cycle phase times are modeled as random variables and a formula for the expected fraction of cells in S phase as a function of time is established. The model is compared to data from the literature and is also compared to previously suggested deterministic and stochastic models.
Document Object Identifier (DOI)
Olofsson, P., & McDonald, T.O. (2010). A stochastic model of cell cycle desynchronization. Mathematical Biosciences, 223(2), 97-104. doi: 10.1016/j.mbs.2009.11.003