Title
Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies
Document Type
Post-Print
Publication Date
2009
Abstract
A new family of guanidinium-rich molecular transporters featuring a novel oligocarbonate backbone with 1,7-side chain spacing is described. Conjugates can be rapidly assembled irrespective of length in a one-step oligomerization strategy that can proceed with concomitant introduction of probes (or by analogy drugs). The new transporters exhibit excellent cellular entry as determined by flow cytometry and fluorescence microscopy, and the functionality of their drug delivery capabilities was confirmed by the delivery of the bioluminescent small molecule probe luciferin and turnover by its intracellular target enzyme.
DOI
10.1021/ja907363k
Publisher
American Chemical Society
Repository Citation
Cooley, C. B., Trantow, B. M., Nederberg, F., Kiesewetter, M. K., Hedrick, J. L., Waymouth, R. M., & Wender, P. A. (2009). Oligocarbonate molecular transporters: Oligomerization-based syntheses and cell-penetrating studies. Journal of the American Chemical Society, 131(45), 16401-16403. https://doi.org/10.1021/ja907363k
Publication Information
Journal of the American Chemical Society